ZITHROMAX (azithromycin)Zithromax (azithromycin) is an antibiotic that fights bacteria. It is used to treat a wide variety of bacterial infections. It is a macrolide-type antibiotic. It works by stopping the growth of bacteria.Mechanism of action:
It is used to treat certain bacterial infections in many different parts of the body. This medicine may mask or delay the symptoms of syphilis.
It is not effective against syphilis infections.It is belongs to the class of drugs known as macrolide antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.
Indications:This drug is used to treat many different types of infections caused by bacteria, such as respiratory infections, skin infections, ear infections, and sexually transmitted diseases.Precautions: Should not used this drug if you have,
Have liver disease or failure
Have kidney disease or failure
Have any heart problems
Have myasthenia gravis
Are pregnant or thinking of becoming pregnant
Have any allergies to medications
Will be having any surgery.
Side effects:Stomach upset, diarrhea/loose stools, nausea, vomiting, or stomach/abdominal pain may occur. serious side effects occur: hearing loss, eye problems (e.g., drooping eyelids, blurred vision), slurred speech, muscle weakness, dark urine, persistent nausea/vomiting, severe stomach/abdominal pain, yellowing of the eyes or skin.Dosage:
These tablets are to be taken 500mg single dose for the first day and 250mg in the 2nd-5th day of treatment. The tablets may be taken with or without food.
For the treatment of genital ulcers a single dose of 1000mg should be use.
For the treatment of urethritis and cervicitis a single dose of 2000mg should be used.
Aluminum-and magnesium-containing antacids reduce the peak serum levels (rate) but not the AUC (extent) of its (500 mg) absorption.
Administration of cimetidine (800 mg) two hours prior to this medicine had no effect on its (500 mg) absorption. A single oral dose of 1200 mg azithromycin (2 x 600 mg ZITHROMAX tablets) did not alter the pharmacokinetics of a single 800 mg oral dose of fluconazole in healthy adult subjects. Total exposure (AUC) and half-life of azithromycin following the single oral tablet dose of 1200 mg were unchanged and the reduction in Cmax was not significant (mean decrease of 18%) by coadministration with 800 mg fluconazole. A single oral dose of 1200 mg this drug(2 x 600 mg ZITHROMAX tablets) had no significant effect on the pharmacokinetics of indinavir (800 mg indinavir tid for 5 days) in healthy adult subjects.
This product is contraindicated in patients with known hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic.
Zithromax is contraindicated in patients with a history of cholestatic jaundice/hepaticdysfunction associated with prior use of azithromycin.